化妆品稳定性研究的参数

由于近来过去的过去，化妆品已经在使用中已经使用了，但由于提高意识，您对个人医疗保健和美容产品的需求一直存在升级。美国和欧洲联盟传统上是主要市场，但其他发展中经济体也有助于这些产品的市场增长。全球监管机构提出严格的要求，以确保安全使用化妆品，这些要求还包括稳定性研究，保证产品在保质期内保留其宣布的特征。

Stability Test Parameters

设计了化妆品的稳定性研究，以确保产品或改性版本符合预期的物理，化学和微生物质量标准以及在规定条件下储存时的功能和美学。这种测试在三个课程下逐渐发言：

身体的：chemical: appearance, colour, odour/fragrance, viscosity, texture, flow and emulsion stability, density, refractive index, light stability, etc. Accelerated stability testing is used to arrive at the expiry date of the product.

微生物学：污染细菌，霉菌和酵母生长。

包装兼容性：包装的完整性和在预期的储存条件下的产品。

Cosmetic and personal healthcare products fall in several usage categories and sub-categories.It is not possible to elaborate upon details of stability testing on all the categories and in this brief article an attempt is made to outline some of the general test parameters.

Physical/Chemical Tests

Light exposure often leads to discolouration of the product or the package/label.
离心机试验用于测试乳液的稳定性。将乳液层或油滴的分离称为奶油。将乳液加热至50℃并以3000rpm离心30分钟。
Temperature cycling at elevated temperature provides accelerated stability testing. Some tests are conducted at 45°C or 37°C for three months. Routine room temperature studies (25°C) are required to be conducted for two years. Freeze – thaw cycling reveals detail on product stability. It is done at 0°C or -10°C. Product is kept at -10°C for 24 hours and at 25°C for next 24 hours (referred to as cycle). A product passing these cycles tests is considered stable. If the temperature is cycled between -10°C and 45°C for three 24 hour cycles it is considered to be a high-quality product.
完成机械冲击测试以确定运输运动是否会损坏产品或其包装。在这种测试的不同阶段，可以进行颜色，香味，粘度，pH值，粒径等。

包装

包装防止产品与环境相互作用。它通过空气或暴露在水蒸气中保护产品免受氧化。同时，它通过蒸发挥发性组分来防止稀释损失。包装的测试包括泄漏测试，减肥测试和惰性容器中的测试。

Microbiological Stability Tests

Microbiological contamination can result during manufacture, transportation or during usage by consumer. It can result in deterioration of quality of the product. Screening tests using rapid semi qualitative or quantitative tests involving enrichment culturing and colony counting are often employed.

In a subsequent article stability chambers will be covered which are used for conducting stability studies on a range of products covering pharmaceuticals, foods and cosmetics.

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